The BCL-2 family of proteins plays a pivotal role in the regulation of apoptosis^1-3

Resisting programmed cell death is a key hallmark of cancer—and BCL-2 inhibition is a rational approach to inducing apoptosis in haematological malignancies.^1,4

BCL-2=B-cell lymphoma 2.

References: 1. Adams JM, Cory S. The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene. 2007;26(9):1324-1337. 2. Plati J, Bucur O, Khosravi-Far R. Apoptotic cell signaling in cancer progression and therapy. Integr Biol (Camb). 2011;3(4):279-296. 3. Czabotar PE, Lessene G, Strasser A, Adams JM. Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy. Nat Rev Mol Cell Biol. 2014;15(1):49-63. 4. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000;100(1):57-70.